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Alright, thank you very much, Fiona. Okay, so, yes, I will have seen a few of you before in the previous lectures and possibly some of the classes as well.
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But today what we're looking at is the history of vaccination. Okay and so I will start by sharing my slides.
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Much more interesting than looking at me. So.
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And there was me, I'd set it to start and I've gone and it's not. Here we go.
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Right, there we go. Oh. Well, we just start that first page with the introduction and he was just saying about vaccinations.
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Okay, and it's just in introducing it. So what I'm just going to say is before I start all of the information.
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Found that I have I'm going to display to you in the, in, the slides and with me talking.
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All of that information has come from a few sources. Now there is an associated document of further reading and resource and sources of the facts, available from Fiona if you want it.
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But in in a nutshell, the definitions, the facts have all come from a few places.
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So we've had the World Health Organization. Time Magazine, Harvard University. Our world data and the UN.
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Okay. And also, our government website as well, the British government websites. So that's where all the information has come from and if you want to check back you will be able to find it in one of those sources.
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Okay, so we just thought we'd start with that. This one at the bottom, this is the, is the Oxford dictionary online.
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Okay. And that's why I put this source on the bottom of this. But they were taking up too much space on the side.
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Okay, so we've got definitions. So start with, we have got various definitions. We've got inoculation.
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Vaccination and vaccine. So inoculation really and vaccination these days are interchangeable. Absolutely interchangeable terms.
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Okay, so when you inoculate someone you're immunizing against a disease you're introducing in effective matter or material microorganisms or a vaccine into the body.
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Vaccination is the actual introduction. That's the that's the needle part or the Oh yeah, on the sugar queue part.
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Vaccination is the process of getting that vaccine. Okay. And a vaccine is a substance used to stimulate immunity to particular infectious diseases or pathogens.
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Okay and they're usually prepared from inactivated or weakened forms of the pathogen that causes the disease.
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Okay, so just to start you off with that. Okay, so next slide. Oops, sorry.
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That's my fault. Right. I'm so sorry. It's very, very rare for me to do this.
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And I don't know why, but we're not, won't let me go back.
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So we're just going to miss the. Sounds terrible. So it's very, very, not very professional, is it?
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The last slide when I clicked through by accident because I was trying to move your faces off my screen.
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That one. All it showed you was a timeline of vaccination, okay? And we're going to have another one later on, but particularly what it started with was smallpox.
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The very first vaccination was against smallpox. And then we went through from sort of the 17 well proper crop smallpox vaccination started in 1798.
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That's the gender one and we were looking through to the present day and obviously that led to the kovat vaccine that was produced in very, very short time.
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But what I'd like to do is just say that smallpox is interesting because It is the only, micro or pathogen that we have managed.
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To eradicate in the wild using vaccination. And it's been extremely successful and it took a whole world approach to be able to do that.
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Currently the world we are trying to eradicate polio. We're doing quite well with polio with vaccination around the world.
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But there are certain pockets in certain countries and pockets within those countries where we have just not managed to eradicate it in the wild yet.
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Okay, so I'm going to just start with smallpox. So smallpox is caused by a virus.
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It's a variola virus. Okay. 8 kills one in 3 infected people.
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This is why when Scientists, doctors, governments were trying to look at eradicating certain diseases.
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Smallpox was one that they really, really wanted to to get rid of. Mainly because It kills so many people.
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In the sixteenth, seventeenth centuries, if when a ship ships were trading around the world, you would find that if a ship had smallpox on it then the when they came into port, they usually they were turned away.
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There were there were instances of ships being set on fire. Because people were so scared of smallpox.
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People at that time were so frightened of smallpox because it killed one in 3 of you. So if you had a family of 9, 3 of you would die from it.
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Which is a huge It's an awful lot of people. And it's a very unpleasant disease.
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Okay, it only affects humans and that is part of the reason why it We were able to actually eradicate it.
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There is no animal, sort of sink. For the virus for smallpox because it only affects humans.
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So that made it a lot easier for us to actually. Completely eradicate. Okay.
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The first inoculations for smallpox were surprisingly enough, probably in China. Now I've given the date of the fifteenth century or earlier.
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But they're all reports and I couldn't cooperate them so that's why I didn't put it down but there are reports that't put it down but there are reports that probably in China from the tenth century.
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The, that they were, they were trying, they were inoculating against smallpox.
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Okay. So at that time, you know, China was, an extremely Oh, with thinking, country.
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So fifteenth centuries a long time. What happened though is that we do absolutely definitely know that by the early eighteenth century there was vaccination of a type being conducted in the middle east.
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They're all actual retirement records for that. We know that happened. Okay. So this is the lady.
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She's very interesting. She's one of our female scientists who's, well, she's not really a scientist, but she is somebody who is actually being recorded in history.
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So Lady Mary Wellsley, Montague was of Quite a wealthy family. She contracted smallpox.
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When she lived in England. And she did survive, she was, she was the 2 out of 3 that survived.
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But she had severe scarring. Smallpox generally scars on the face. Most the worst scarring is on the face.
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She lost her And she had red and sore eyes for the rest of her life. Many people who survived smallpox went blind.
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And they lost the site altogether. So as you can see, even if you survived it, it really wasn't a very nice thing to have had.
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Nice. Lady Mary. Married and she and her husband moved to Turkey and she was very interested because she had this terrible scarring on her face and she noticed that in Turkey there were very few people with such severe scarring.
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She saw people who had a little bit of scarring but nothing like hers. And she was interested to find out why.
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And she found that local women were using a very, very early form of anoculation. And the way they did this was, you'll be a bit shocked about this, I'm sure.
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But what they did was, they would have like this, I'm sure. But what they did was, they would have like little, you know, today or, and they would have like little, you know, today or certainly in the last sort of 2030 years, certainly in the last sort of 2030 years, people used to have chicken pox parties, in the last sort of 2030 years, people used to have chicken pox
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parties. People used to have chicken pox parties to do that invite, invite all the friends around because one child chicken box and that's fine.
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Well, in Turkey at that time they would have like, invite all the friends around because of one child chicken box or get it and that's fine.
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Well, in Turkey at that time they would have like gatherings in the autumn for smallpox and all get it and that's fine.
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Well in Turkey at that time they would have like gatherings in the autumn for smallpox and what they would do with the older women in the, would have like gatherings in the autumn, for smallpox and what they would do with the older women in the communities would find somebody who had smallpox.
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They would take plus actual pus from the postules of the smallpox patient. And then what they would do was with the local children.
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They would make a very, very small little cot in the child's arm. They would rub in the actual smallpox pus into that little cut and they bind it up really tightly with a bandage.
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And that child would go on to develop a very very mild bout of smallpox, really mild.
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And then they were immune for life. So, very, very interesting. This is, Lady Montague thought this was very interesting.
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Now the reason that these children did not develop full-blown really really bad smallpox was because smallpox is actually an airborne disease.
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In the same way as colds, flu and COVID. It's an airborne disease. And when it enters the airways because your respiratory system is very moist, it's very surprisingly big, it's got a huge surface area, your lungs, your sinuses and everything.
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If you, if you contract some other pops like that, you get full blown smallpox.
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But when it's just introduced under the skin. Then you do not get all of the symptoms. It's a much, much milder way of developing the disease.
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So she had a little girl and she decided that she'd have her little girl vaccinated. Let's her little boy, sorry, her little boy vaccinated in Turkey by a local woman.
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Obviously people were a bit, you know, worried about this. It's a risky thing to do, but having survived smallpox herself and having known how unpleasant an illness it was.
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But how lucky she was to survive, how lucky she was to still have her sight. She wanted to protect her children.
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So her little boy was vaccinated in Turkey. And then the family moved back to England. And in, 1,700, and 21, she arranged for her daughter to be vaccinated in England by a doctor who had experience of he'd been to the Middle East himself and he knew how it was done.
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So it was an English doctor that did it. But it was the same method. And this generated a significant amount of interest at court.
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And of course, in those days, the people at court, where the wealthy, the powerful, the influential.
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And so many people. In wealthy families started to let their children be vaccinated in this way. Of course it is a risky way of vaccinating because it you're using that actual live.
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And so, you know, there will be some Kash, casualties along the way. But it's better than nothing.
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So. This is timeline for immunisation against smallpox. So obviously it was Lady Mary in the very early 17.
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Sort of twenties. But then, and with Jenna, you'll all know this story, Edward Jenner.
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Discovered that milkmaids were unlikely to get smallpox. Providing they have been infected with cowpox.
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He discovered that if you use cowpox pus as a vaccine, then you would introduce a mild form of cowpox which would give you immunity against smallpox.
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The actual viruses for the 2 are quite closely related. They're similar enough for your body to promote, to promote an, an immune reaction within your body in, within your white cells.
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And that's immunity lasts for life. And this was a game changer because Calpox is generally it's not a it's not a killer.
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It's not a killer like smallpox. But it was safer. It really, really worked.
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And what they tend to do, they didn't really go for the cut, so much, they used to scrape the skin, open up the skin a bit and rub it in like that.
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So that was 1896. That's sorry, 1. 96, a long time ago.
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In the 18 forties and fifties. In many countries around the world, including Britain, parts of the United States.
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Many other countries within Britain particularly within Europe. Smallpox vaccination became mandatory. You had to have it if you wanted to travel.
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And that led to smallpox vaccination certificates and you have to have those for travelling. I'm sure many of you in this call will have a yellow fever certificate.
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For travelling. That used to be, that's mandatory in some countries around the world today.
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By 1958. Smallpox vaccination had been extremely successful and the cases around the world were dropping and dropping and dropping.
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The deaths were dropping. And the WHO, the World Health Assembly, called for the global eradication of smallpox.
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And they decided that we got so far that the end was inside. And if everybody worked together, we would get rid of it.
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I'm sure there are some of you on this call who will actually have a little scar on your arm.
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About the size just just a little bit bigger than a penny. And that will be a smallpox vaccination scar that you may have had.
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And if you haven't got one, I don't have one. But my mother and my father did.
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So it's within living memory that people were actually being vaccinated. Against smallpox. By 1,980.
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The WHO declared that smallpox was actually officially completely eradicated in the wild in the world.
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And that was a huge, huge breakthrough. So we don't worry about smallpox anymore.
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We don't have to worry about it. We're not going to catch it. Even though the majority of us now.
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Have not been vaccinated against it because we didn't need to be vaccinated. I'm a child of the sixties.
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I'm just going to put that out out to you. I didn't get the vaccination because in the UK by the time I was a child I was a baby.
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There's so many people in so many adults in the past generations have been vaccines to get smallpox that smallpox was pretty much eradicated in Britain.
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So, I didn't get a vaccine. They stopped doing the wholesale vaccination of, children.
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Now, this is, an American, graph. This actually came from Harvard University. And this is just to indicate the death rates of smallpox and what a game changer to vaccination was.
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So this is the death rates in Boston. And U.S.A. and as you can see though they fluctuate in the way that all diseases do with diseases often come in cycles you have badgers you have good years you know so on.
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But if you have a look at this. When in 1,800 the first tie is first use of vaccine in Boston occurred.
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Many people in Boston were vaccinated from there onwards. And the rates of deaths from smallpox.
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Plummeted. Absolutely plummeted. So you went from, in 1721.
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Nearly 8,000 people a year dying 8,000 sorry 8,000 per 100,000 people a year dying from smallpox 2, well, at the worst.
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52.1 there must have been a bit of a blip in between 1937 and 1873 and I don't know what that was I don't know whether it was maybe to do with war or anything I don't know.
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U.S.A. history, but there was obviously a bit of a blip because the cases went up. Having said that, they were still not up to the weights that they had been.
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Before vaccination.
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Okay, so smallpox today has actually been eradicated in the wild.
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All governments have a stock of vaccine. It is a live type vaccine. Okay, it's not dissimilar to the one that Jenna used.
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It's not quite the same, but it's not dissimilar. So it's a live vaccine.
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That means that if you have certain, If you're, you know, compromise.
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You're taking certain medicines. You're not able to have that type of vaccine.
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Okay, officially 2 labs in the world have samples for smallpox. They are in the ones in russia and ones in Atlanta in U.S.A. Okay.
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There are, I know that, Portland Down has got a little stock and I think that is used for We research.
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And what we're really, really, really worried about these days in the world is the fact that smallpox could be used as a biological weapon.
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Because basically there are very, very few of us now in the world who have actually been vaccinated against it.
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And so. This is something that we are worried about.
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Because we know it kills people. Okay, right, so we're looking at the development of other vaccines.
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Now before I get onto that, I am just going to give you a little bit of potted history.
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So in the nineteenth century The biggest cause of death from disease and this is not including heart disease cancer. So this is just.
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To communicable diseases. The ones that you can catch from other people. In the nineteenth century.
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People were dying from TV. They were dying from whooping cough, diphtheria, rabies.
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Tatness, whooping cough, all of those things. By 1,900 and flu in the early 19, well, 1919, 1919, Spanish flu.
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We don't call it Spanish flu anymore. It didn't originate in Spain. It was just that's the way we all remember it.
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But the big flu pandemic in 1918, 19, there were reasons for that. A lot of it was to do with war.
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Bit the war and what happened was the war enabled it the spread of it very very quickly. But that was a massive pandemic.
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And I have got figures, 50 million people at least in the world, 50 million people at least in the world died in 1,918.
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And because of flu. 50 million. And just imagine that in those days the population, the total population of the world was significantly lower than it is now.
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As a sort of, you know, comparison. The UN, has estimated that We have had deaths associated with COVID, not due to COVID, but deaths either due to code or due to complications of kovat or associated with kovat.
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We think that 15 million people have died in 202-02-0210kay, and those 2 years.
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So that's 15 million. Associated with COVID against 50 million. In 1918 19 with the flu.
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That's that just puts COVID into perspective. And of course there are reasons why COVID didn't.
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Kill as many it would have done. But it didn't. Okay. And in the nineteenth, twentieth century, flu obviously was a big a big killer because of that pandemic.
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People were still dying of TV. They were dying of children die of diarrhea that happens in countries all over the world today.
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Children were dying of diphtheria. Cholera and twist. No, we don't tend to, what happened with cholera and typhoid was that It was found that they were waterborne diseases and with improvements within sewers, water treatment, piping of water and so on.
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We were able to contain those. Without having to look too much. That's vaccines, although vaccines were were produced.
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Okay, so the reason that we developed all these vaccines was so that people wouldn't die. I mean, it was as simple as that.
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Okay. You must remember that in the past, you know, a lot of these, diseases were caused by viruses.
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And it is only quite recently that we've been able to have any treatment against virus at all apart from immunisation.
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Other diseases that were caused by bacteria but of course pre, 19 forties, we had no antibiotics.
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And so people would die from bacterial infections. So, you know, scientists were looking at ways of trying to reduce.
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Reduce the deaths. By different means. And that's really why vaccines were were being developed.
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So in 1,885 pastor okay and well we've heard about him and we didn't actually it was Jenna but pasta developed a vaccine for rabies pasta was very hot on developing vaccines.
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And 1896 we had typhoid and cholera. In the 19 hundreds. In the 19 forties.
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Game changer, flu vaccine. That was the first flu vaccine was produced and I'll send it theory and polio.
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Okay. My mother remembers. Children dying of dictionary. I think she lost one of her sisters to diphtheria and she just remembers like a membrane at the back of her throat.
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We got to 1,957 and the whooping cough or petosis vaccine was produced.
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I, I remember I was at school with a girl who had, she called whooping cough.
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She was, about 1112. She caught hooping cough, she was off school for a month.
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She came back and she couldn't do games or anything for about 3 or 4 weeks afterwards.
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In the 19 sixties we developed vaccines against Okay, Rebella doesn't kill people.
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But if you if a pregnant woman contracts, in the first 3 months pregnancy, and it is associated with congenital birth defects.
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So it was important, although the mum, the pregnant woman wouldn't die, and her baby would have would be altered for life.
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Just because of the Mabela and that's why that was introduced in particular. Okay. I remember having, I didn't have a vaccine against a time, just a little bit too old.
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And, I remember my parents being absolutely scared to death that I would end up blind or deaf.
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Or have meningitis. I think, you know, this is what I think.
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But sometimes we forget how bad some of these diseases were. Good. So in the twentieth century, here we go.
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This is, 20 first century. So this is, this is more at the current time. So we developed, pneumococcal vaccines in the 2,000.
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And pneumococcal vaccines. And they prevent the main cause of pneumonia.
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And pneumonia kills people or many people, especially when you're older, if you if you develop new ammonia, then you can be very, difficult to get better from it even with modern medicines and modern hospital.
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It can be particularly difficult. And pneumonia can be caused by viruses as well. So the vaccine, for new, a pneumococcal vaccine.
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Helps prevent pneumonia. You only need it the once. It's not like the MMR.
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All the rabies that you need to have don't really sorry tennis that you need to have boosters for new macock we have it once and you've had that's it.
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It's done. You're right. You're in. In the 20 tens we developed via vaccines against shingles.
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Rotor virus which is a diarrhea type It causes diarrhea. And a children's flu virus.
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A children's flu vaccine was developed in the 20 times. So it's about it's slightly different to the one that you will get.
00:30:18.000 --> 00:30:33.000
If you have if you're eligible and you get one in the winter, the children's one is not quite the same as the one that, is used for adults.
00:30:33.000 --> 00:30:51.000
So in the 20 tens, I mean you can just see how development of vaccines has really, really speeded up and this is the big thing now you know when the The earliest vaccines, they took a long time.
00:30:51.000 --> 00:30:58.000
I mean, we started in the 17 sort of sixtys with smallpox and things were just gradual, gradual, but now we've got to the 20 first century.
00:30:58.000 --> 00:31:19.000
We are, producing vaccines now much much more quickly. So in the 2010 we also have one against many injocal meningitis.
00:31:19.000 --> 00:31:27.000
HPV, that's the human papillo. I just left it as a HVV because I can't take word and Papillo virus.
00:31:27.000 --> 00:31:32.000
It's the one that is, I can't say a word, and the Papillo virus, it's the one that is, is highly associated with Secycle cancer.
00:31:32.000 --> 00:31:42.000
Okay, I think it's 98% of cases of cycle cancer are linked to HPV virus.
00:31:42.000 --> 00:31:53.000
We've also, introduced, an Ebola. Vaccine and a vaccine against monkey pox which obviously was not only news not so long ago.
00:31:53.000 --> 00:32:05.000
Because that again is so it was spreading very very quickly. So not all of us are going to be given all of these vaccines apart from the HPV now and and the minage cockle babies get that one and HPV is given to teenagers.
00:32:05.000 --> 00:32:15.000
They start off just giving it to girls. It is a 3 jab vaccine. You have to have it 3 times.
00:32:15.000 --> 00:32:30.000
To get full protection. And they started giving it to just girls, but now it's being, I think it should have always been this way.
00:32:30.000 --> 00:32:36.000
It's been introduced for boys as well. So teenage girls and boys will get the HPV.
00:32:36.000 --> 00:32:38.000
Vaccine. And that should make in the in the future that should really really reduce the cases of cycle cancer.
00:32:38.000 --> 00:32:54.000
So what we're doing here is we are not vaccinating. We're vaccinating, vaccinating against HPV, but HPV doesn't kill you.
00:32:54.000 --> 00:32:59.000
But the associated cancers can. And the actual fact HPV is also associated with some oral cancers as well.
00:32:59.000 --> 00:33:12.000
And some peanut comes as 2, which is why it's really, really important that boys and girls both have it.
00:33:12.000 --> 00:33:25.000
Okay, and then we get to the 20 twenties Well, 2020. COVID the COVID vaccine and that was produced in a very, very short space of time.
00:33:25.000 --> 00:33:34.000
That very short space of time. And we've got some slides coming up. Which I will explain why that one came up so fast.
00:33:34.000 --> 00:33:42.000
Okay. So next one. So we have got various vaccines. Okay.
00:33:42.000 --> 00:33:49.000
And they are. Classified into 2 sorts really. So you have you have live vaccines or attenuated vaccine.
00:33:49.000 --> 00:34:04.000
So a line vaccine is, the, those that are used for smallpox. Polio?
00:34:04.000 --> 00:34:12.000
MMR rotovirus The diarrhoea one, smallpox, I'm sorry, smallpox fries and chicken box.
00:34:12.000 --> 00:34:19.000
Okay, it is possible to get a vaccine against chickenpox. But obviously chicken pox is a generally a mild disease.
00:34:19.000 --> 00:34:30.000
Chicken pox is not caused by a variola virus. Okay, but what chicken pox does do is chicken pox You have it the once, you're immune for life once you've had it the ones, but the virus stays within your body.
00:34:30.000 --> 00:34:39.000
It lives in nerve cells. It's what seconds itself down. In a little nerve cell somewhere.
00:34:39.000 --> 00:34:51.000
It can be reactivated, reactivated in times of severe stress, severe illness and so on and that is shingles.
00:34:51.000 --> 00:34:56.000
So I'm sure there are more than one of you here in this call who's had shingles.
00:34:56.000 --> 00:35:09.000
It is incredibly painful. And once you've had it the once, it tends to sort of It goes, and you can, there are antiviral drugs you can take for it.
00:35:09.000 --> 00:35:17.000
But if you've had it the once sometimes it will, you know, if you're a bit run down, it'll, it'll reactivate a little bit.
00:35:17.000 --> 00:35:24.000
Okay, so that's really why you've looked at developing, the chicken box vaccine.
00:35:24.000 --> 00:35:28.000
Okay, so.
00:35:28.000 --> 00:35:35.000
Let's get to the next ones. So these are inactivated. vaccines.
00:35:35.000 --> 00:35:59.000
Okay, so the last one's were live or attenuated. So live meant life, actually living, attenuated mint just changed a little bit so it wasn't going to cause the disease okay they might just change a little bit of something in the protein code and it would just not cause the disease but would cause an immune reaction from your immune system.
00:35:59.000 --> 00:36:15.000
Inactivated via vaccines are things like the MRN, MRNA vaccines, okay, and that includes COVID vaccine.
00:36:15.000 --> 00:36:25.000
You have some which. Have this is complicated but basically what they do is they take one little bit of the actual pathogen.
00:36:25.000 --> 00:36:30.000
It might be the coat, if it's a virus, you get a protein coat round it. They might take the protein code, they might take a little bit of the material inside the virus.
00:36:30.000 --> 00:36:46.000
What they do is they try and take a little bit of the virus or the back area which is causing the disease.
00:36:46.000 --> 00:37:03.000
And they can. Introduce it into your body but What happens is that the bit that they take out will cause your immune system to, to mount an immune response, you will make antibodies.
00:37:03.000 --> 00:37:12.000
You will make white cells that remember that particular pathogen. But it won't cause the disease.
00:37:12.000 --> 00:37:25.000
Okay, so these are very safe and these types of vaccines can be taken by more people. So they include things like the hip vaccine.
00:37:25.000 --> 00:37:32.000
The hepatitis B, HPV, the whooping cough, pneumococcal, minging jockey and shingles.
00:37:32.000 --> 00:37:36.000
Okay.
00:37:36.000 --> 00:37:53.000
. Time There are some vaccines which are called toxic toxoid vaccines. Now these some pathogens produce a toxin and it's the toxin that makes you ill.
00:37:53.000 --> 00:38:08.000
So the toxin you can make a vaccine using the toxin Changing it very, slightly so that A body's immune system recognises it as foreign?
00:38:08.000 --> 00:38:18.000
And if it recognizes it as foreign, it mounts and an immune response. And so you will become you'll get an immunity from it.
00:38:18.000 --> 00:38:34.000
So toxoid vaccines are the dip theory of vaccine and the tetanus vaccine. Okay, so those 2 vaccines are made from the poison, the toxin that the organism produces.
00:38:34.000 --> 00:38:43.000
And it's it will give you immunity. Then you have what are called vile vector vaccine. So that's like COVID.
00:38:43.000 --> 00:38:48.000
19. And basically what they do is they take a little bit of the virus. They take the bits that your body recognizes as foreign.
00:38:48.000 --> 00:39:01.000
The bit that you're immune, your white cells recognize as being foreign. And they put that into a vaccine.
00:39:01.000 --> 00:39:10.000
And then your body recognises this as being foreign. And, and the mean response. COVID-19 is one of those.
00:39:10.000 --> 00:39:15.000
Oh, oh my goodness, I finished too early. Oh, that's not very good, is it?
00:39:15.000 --> 00:39:23.000
Okay, well, let me just stop the share because what I would like to do because I missed a little bit out at the beginning.
00:39:23.000 --> 00:39:31.000
Because Cause I went through the, yeah, I missed, cause I missed the slide to be honest. It was my fault.
00:39:31.000 --> 00:39:37.000
So what I would like to say is, and this has come from the Office of Natural, National Statistics, and I think this is extremely interesting.
00:39:37.000 --> 00:39:59.000
Is that once immunization was introduced to countries there was a dramatic decline in deaths. Now if you want to go and see the actual figures you go on to the Office of Natural, National Statistics website and have a look.
00:39:59.000 --> 00:40:04.000
I had a look at them and I didn't want to put slides on because they were too complicated.
00:40:04.000 --> 00:40:10.000
You wouldn't have seen them, especially if you're looking on the small screen. Okay, but once.
00:40:10.000 --> 00:40:22.000
Vaccines were introduced against polio. Dipheria, tetanus. Whooping cough and measles, mumps and rubella.
00:40:22.000 --> 00:40:33.000
There was a dramatic decline in deaths. From those diseases. And I think sometimes we forget that these these diseases do call do cause death.
00:40:33.000 --> 00:40:44.000
And often disability. Okay. So I think that's it. I'm really sorry that I've finished so early.
00:40:44.000 --> 00:40:48.000
That's got myself. I don't know what I got myself. Oh, so I'm finished too early.
00:40:48.000 --> 00:40:56.000
The other thing. No, that's it. That's it. So Fiona, would we like to go to our any questions that we've got?
00:40:56.000 --> 00:41:06.000
Okay. Yes, we've got some here and thanks very much for that. We'll just go straight into the questions now.
00:41:06.000 --> 00:41:13.000
Let's have a little look. Now. You mentioned this a few times. Diseases being eradicated in the wild.
00:41:13.000 --> 00:41:20.000
What exactly do you mean by that? I would assume that You mean within the general population of the world basically.
00:41:20.000 --> 00:41:31.000
Yeah, yes, definitely within the general population. So the thing is, when diseases are, when you catch something, it's because you get it from somebody.
00:41:31.000 --> 00:41:37.000
You know, so say if I, if I catch cold, I will have got a cold from somebody else.
00:41:37.000 --> 00:41:40.000
They, they'll, you know, sneeze coughed, touch something, whatever.
00:41:40.000 --> 00:41:51.000
I, I would have caught it from them. But if there, if If people have been vaccinated, they will not catch those diseases.
00:41:51.000 --> 00:41:57.000
And if you have, if you have fewer and fewer people who are able to catch those diseases. Then if you have fewer fewer people who are spreading them.
00:41:57.000 --> 00:42:12.000
And so the more and more people who have been vaccinated, the fewer and fewer people are spreading the disease and the disease will just.
00:42:12.000 --> 00:42:20.000
If it can't be, if it can't be. Transmitted. Then it's going to go.
00:42:20.000 --> 00:42:26.000
So say say say there was somebody in Hi, mountain cave, you know. Somebody who lived completely on their own.
00:42:26.000 --> 00:42:36.000
And they, They contract, they've gone into town, they contracted smallpox.
00:42:36.000 --> 00:42:47.000
But they went back to their cave. And was ill, they might be ill, they might have survived, they may not have survived, but during all that time they're real because they live completely on their own.
00:42:47.000 --> 00:43:02.000
They're not transmitting the disease, so it's not going further from them. And so the more people who are actually immunized, the less chance diseases have to be transmitted.
00:43:02.000 --> 00:43:03.000
Okay.
00:43:03.000 --> 00:43:08.000
Okay. And that question was from Leslie, so I hope that answered your question, Leslie.
00:43:08.000 --> 00:43:09.000
So, Yeah.
00:43:09.000 --> 00:43:16.000
And, people are asking, would it be possible for to actually see the slide that we missed?
00:43:16.000 --> 00:43:17.000
Is it possible? We launch and let's just have a quick look at it. I think it was a quick timeline, wasn't it?
00:43:17.000 --> 00:43:28.000
Oh yes. Yes, let's relaunch right. And it was a very quick timeline to be fair, but let me just go past.
00:43:28.000 --> 00:43:35.000
I'm sorry about that. It was completely by my fault. That's this one.
00:43:35.000 --> 00:43:38.000
There you go.
00:43:38.000 --> 00:43:45.000
There we are. There we go. This is the one we missed. I'm very, very sorry about this.
00:43:45.000 --> 00:43:56.000
So basically, it was a nicer picture than the other one. So in the eighteenth century, we were looking at the smallpox vaccine in the nineteenth century we were looking at the smallpox vaccine we were looking at the smallpox vaccine.
00:43:56.000 --> 00:44:01.000
In the nineteenth century, it was typhoid and rabies was developed. In the nineteenth century it was typhoid and rabies was developed.
00:44:01.000 --> 00:44:02.000
The vaccines against both of those were developed. The vaccines against both of those were developed. The vaccines against both of those were developed.
00:44:02.000 --> 00:44:06.000
Okay. And of course in the nineteenth century as far as typhoid, the vaccines against both of those were developed. Okay.
00:44:06.000 --> 00:44:07.000
And of course in the nineteenth century as far as typhoid was concerned as well was in the nineteenth century as far as typhoid was concerned as well was certainly in Britain.
00:44:07.000 --> 00:44:21.000
We started to have much better water, as far as typhoid was concerned as well, was certainly in Britain, we started to have much better water, cleaning, systems and sewage systems.
00:44:21.000 --> 00:44:22.000
Well, we're certainly in Britain. We started to have much better water, cleaning, systems and sewage systems.
00:44:22.000 --> 00:44:32.000
So once, we sorted out, our sewage system got water treated and kept our drinking water completely separate, that made a huge difference in itself to typhoid in the UK.
00:44:32.000 --> 00:44:39.000
But there was a vaccine produced because it was a, it kills an awful lot of people to kind of typhoid.
00:44:39.000 --> 00:44:48.000
Then we got to the twentieth century, so we looked at as I said before, we had the flu vaccine and interestingly the this is better slide in the way that it's got some names on it.
00:44:48.000 --> 00:45:06.000
The influenza influenza vaccine was produced by Thomas Francis and Jonas Sulk. Sulk was a name that you will hear and can with vaccines.
00:45:06.000 --> 00:45:19.000
There is a salt vaccine and I've got a feeling. I can't remember what it. What it, he immunizes against now, but it's quite famous vaccines, the Sultan.
00:45:19.000 --> 00:45:24.000
I don't think we use it anymore though. I'm sure it's being superseded.
00:45:24.000 --> 00:45:34.000
So and then TV, TV, I'm sure you're aware TB, it was and still is a disease that is.
00:45:34.000 --> 00:45:45.000
As it kills people. It's often the disease of overcrowding but not necessarily. And it was killing an awful lot of people.
00:45:45.000 --> 00:45:55.000
So the vaccine for, tuberculosis was developed in the 1920. And that was the BCG vaccine that many of you will have.
00:45:55.000 --> 00:46:06.000
I've had that one. We don't give the BCG vaccine anymore to children automatically because it is not particularly effective against many of the strains of tuberculosis.
00:46:06.000 --> 00:46:27.000
TB that are circulating. Today. So it's not given routinely anymore. And TB vaccine is usually given to certain groups of people who are more at risk than others.
00:46:27.000 --> 00:46:33.000
Okay. TV is not, it's surprisingly enough, it's not particularly infectious.
00:46:33.000 --> 00:46:51.000
And so you can actually contain TV quite quickly once you have if you have one one case of it it's quite it's not too hard to trace everybody that's been in contact with that person and and vaccinate in small areas.
00:46:51.000 --> 00:47:00.000
Though it's it's more cost-effective but more to the point is that BCG is not Absolutely brilliant.
00:47:00.000 --> 00:47:09.000
Helping with the modern strain. So I was convinced I'd be absolutely fine against TV, but apparently I'm not.
00:47:09.000 --> 00:47:19.000
Then you have, TV is still prevalent in the world today. It's still is a lot of people die from TB today.
00:47:19.000 --> 00:47:29.000
We have TB as a bacterial infection. We do have antibiotics for it, but to get rid of TB, you have to take them for about 6 months.
00:47:29.000 --> 00:47:40.000
So you need compliance. And many people stop taking them, once they feel better. And then the TV comes back and then it's it's mutated so the antibiotics don't work against it anymore.
00:47:40.000 --> 00:47:50.000
So we have a lot of TB. Now, which are, which do not respond to the antibiotics that we have.
00:47:50.000 --> 00:47:58.000
And this is one of the big problems that we have. And this is one of the big problems we have with TV.
00:47:58.000 --> 00:48:00.000
So we really do need, some new vaccines. And this is one of the big problems we have with TB. So we really do need, some new vaccines.
00:48:00.000 --> 00:48:05.000
There, there and being made. Here we go, polio vaccine, that's a silkon.
00:48:05.000 --> 00:48:08.000
That's the one that you had on the sugar cube. You probably remember that it's an oral vaccine.
00:48:08.000 --> 00:48:18.000
And polio is, is a disease that is spread orally.
00:48:18.000 --> 00:48:26.000
And that's one of the sugar cube. And there is another type of polio vaccine now that one is it's an injectable one.
00:48:26.000 --> 00:48:42.000
Okay, then we had peptide speed in 1,969, MMR in 1,971 it was starting to be given to all children okay so although the measles.
00:48:42.000 --> 00:48:57.000
Vaccine had been available in the sixties in the late sixtys the actual combined jab the MMR was developed in the early seventies and started to be getting to children then.
00:48:57.000 --> 00:49:05.000
77, we had the NUMA cockle vaccine, then hepatitis A, 1995.
00:49:05.000 --> 00:49:17.000
And the HPV vaccine that was 2,006 is quite recent is that one. Okay. And then what isn't on this slide and should have been was COVID. I've stuck it on the side.
00:49:17.000 --> 00:49:25.000
I couldn't get it fit on. So they co with vaccine obviously is the most recent one that we are aware of.
00:49:25.000 --> 00:49:26.000
Yeah.
00:49:26.000 --> 00:49:31.000
So that was that was the side we mixed and I'm so sorry we missed it because actually it's a really good slide.
00:49:31.000 --> 00:49:32.000
Thanks.
00:49:32.000 --> 00:49:36.000
Good. Okay. And right. Now, what we've got next now.
00:49:36.000 --> 00:49:43.000
And this is question from Anne. Would we, and I say the word all these, this is Anne's words, not mine, would we all days and I think we're talking about smallpox here.
00:49:43.000 --> 00:49:44.000
Okay.
00:49:44.000 --> 00:49:57.000
And would we all days who have been vaccinated still have immunity?
00:49:57.000 --> 00:49:58.000
Good.
00:49:58.000 --> 00:50:01.000
Yes, yes, it's lifelong immunity, the smallpox vaccine. Yeah. Yeah, so in the case of biological warfare, you'd be okay.
00:50:01.000 --> 00:50:02.000
Yeah.
00:50:02.000 --> 00:50:08.000
Excellent. I hope that answers your question. And a question from Sally, and about the MMR.
00:50:08.000 --> 00:50:09.000
I knew this would come up.
00:50:09.000 --> 00:50:18.000
This website is going to come up, I think. Yeah. And so Sally is saying, getting the benefits of vaccines and the eradication of a lot of diseases.
00:50:18.000 --> 00:50:29.000
Why do you think or do we know why? The uptake of MMR is now really rather low causing quite a prevalence of measles in at the moment.
00:50:29.000 --> 00:50:34.000
And why that is a rise in an anti-vaccination movement since COVID.
00:50:34.000 --> 00:50:42.000
Hmm. Right. Well, let's start with the, the first pass that question, which was, what was the first one?
00:50:42.000 --> 00:50:44.000
NMR.
00:50:44.000 --> 00:50:50.000
MMM, right. So why the rates going down? There's I think there were a few reasons.
00:50:50.000 --> 00:51:08.000
First of all, in the 9, the 19 nineties. There was a, very widely publicized, Study, don't, which associated.
00:51:08.000 --> 00:51:17.000
I'm just going to put it like this. Associated MMR with autism. My son was due to have his vaccines, his MMR.
00:51:17.000 --> 00:51:31.000
The week or so after that came out. So obviously I was I was you know concerned and interested and I delayed this vaccine a vaccination because I wanted to find out more about the study.
00:51:31.000 --> 00:51:35.000
And as it happens, that study, although it was reported widely on the television, in the papers and so on.
00:51:35.000 --> 00:51:45.000
The study was a study of I think it was 6 children. So it wasn't a valid study.
00:51:45.000 --> 00:51:56.000
There were not enough participants within the study to make it statistically, to statistically, viable.
00:51:56.000 --> 00:51:59.000
And I had to look at it. I had a look at other studies. There are many of the studies looking at.
00:51:59.000 --> 00:52:08.000
MMR and autism and the other studies as far as I can find out. Do not show anything at all.
00:52:08.000 --> 00:52:25.000
So my son did have his. Although it was a month or so later than planned. I think a lot of people did not do the research that I did and they just still think that there is a link and I think that's part of it.
00:52:25.000 --> 00:52:42.000
And I think the other part of it as well is that, people, I mean, obviously I, older, like, like, you know, some of you, How I said I remember having measles as a child and I remember how worried my parents were.
00:52:42.000 --> 00:53:01.000
Now, my children have no idea what measles is like. They will have no idea what even to look for with the rash and so on and i think that with younger people they just Do not appreciate the fact that measles and mumps.
00:53:01.000 --> 00:53:09.000
Would cause death or disability. Measles is actually the major cause of meningitis. And I think people don't realize that.
00:53:09.000 --> 00:53:17.000
We're all scared of meningitis. But measles is actually the major cause of meningitis.
00:53:17.000 --> 00:53:18.000
So I think that's that's got a lot to do with it. The anti-vax movement.
00:53:18.000 --> 00:53:25.000
I, that's
00:53:25.000 --> 00:53:34.000
Are you probably gathered that I agree with vaccination? I'm a scientist and so I do agree with vaccination.
00:53:34.000 --> 00:53:39.000
However, people have a choice. They can decide what they want to do or what they don't want to do.
00:53:39.000 --> 00:53:48.000
I think the media, the social media and so on have a lot to do with the anti-vaccination movement.
00:53:48.000 --> 00:53:55.000
There's a lot of misinformation. Around and there's a lot of misinformation with people with agendas.
00:53:55.000 --> 00:54:05.000
So that's my that's my personal opinion. And that is a bit of a political opinion but that I think is why we have this huge anti-vaccination movement.
00:54:05.000 --> 00:54:18.000
And it is driven by certain groups of people with certain ideas. Past the reason that polio is not being eradicated is because of groups in certain countries.
00:54:18.000 --> 00:54:31.000
Who believe that. Okay. I believe that there are. Dark forces involved with the polio vaccination scheme program.
00:54:31.000 --> 00:54:40.000
And and if they if they weren't if they didn't have those particular ideas it would probably be completely eradicated by now.
00:54:40.000 --> 00:54:41.000
Okay.
00:54:41.000 --> 00:54:45.000
So I think it's a lot to do with media. Good. That's my opinion. Okay.
00:54:45.000 --> 00:54:54.000
Okay, right, let's move on. And now we were talking about lots of different vaccines for lots of different diseases.
00:54:54.000 --> 00:54:58.000
A different An, is asking about scarlet fever.
00:54:58.000 --> 00:55:05.000
Scarlett fever! Yes! Scarlett Faber, as far as I'm aware, because I've got a bit of a look.
00:55:05.000 --> 00:55:09.000
I can't find that there is a vaccine against scalar thief. Scala figures horrible disease.
00:55:09.000 --> 00:55:22.000
I think part of the reason that we maybe haven't developed, a vaccine for Scarlet Fever is that it's a bacterial disease and you can treat it with antibiotics.
00:55:22.000 --> 00:55:26.000
So I rather think that that's probably why there isn't a drive. To develop a vaccine.
00:55:26.000 --> 00:55:40.000
Having said that, we are all aware that our our antibiotics are limited. They are reduced.
00:55:40.000 --> 00:55:56.000
Many pathogens are becoming resistance to them. So I it would be quite interesting to see whether that What they, vaccine is produced for scarlet fever in the next sort of 1020 years.
00:55:56.000 --> 00:55:58.000
I wouldn't surprise me if it did. It's becoming quite common again as well. It used to be quite a rare thing.
00:55:58.000 --> 00:56:08.000
Scarlett fever, but I believe cases are going up a little bit.
00:56:08.000 --> 00:56:22.000
Hmm, interesting. And a question from Celia. This is maybe more of a medical question, so I'm not sure whether this is something you did the answer but she's asking about shingles because it seems to be quite prevalent these days as well, doesn't it?
00:56:22.000 --> 00:56:26.000
I am a recent person that's had it very mildly and it's deeply unpleasant.
00:56:26.000 --> 00:56:27.000
Hmm.
00:56:27.000 --> 00:56:36.000
Painful but it's what Celia is asking is why do we get it? Can it be a stress thing or are there other puzzle?
00:56:36.000 --> 00:56:37.000
What are the causes?
00:56:37.000 --> 00:56:45.000
It can be a stress thing. It can be to do with illness. As I said, it's shingles is caused by the virus that causes chickenpox.
00:56:45.000 --> 00:56:46.000
Yeah.
00:56:46.000 --> 00:56:56.000
And once you had chickenpox as I said the virus it finds little place within your nervous system and it will just sit there and You know, go to sleep.
00:56:56.000 --> 00:57:04.000
But sometimes it's Almost woken up by stressful events can definitely reactivate it.
00:57:04.000 --> 00:57:20.000
Illness can often reactivate it some people you have no idea what's reactivated it and my it's a disease more generally of older people, shingles.
00:57:20.000 --> 00:57:29.000
It's very rare for young people to have shingles, but I, my niece actually had shingles as a teenager.
00:57:29.000 --> 00:57:30.000
Hmm.
00:57:30.000 --> 00:57:35.000
Mild case. But that's extremely rare and I don't, we don't know what caused it.
00:57:35.000 --> 00:57:47.000
We don't know she didn't have it. You know, something happened. It just it just appeared, but it's often associated with times of extreme stress.
00:57:47.000 --> 00:58:08.000
Illness and lack of just being run down. You know, my mother-in-law had it after her husband was, admitted to a residential care and that's because she hadn't slept for 2 years, year enough.
00:58:08.000 --> 00:58:11.000
And, she, she was very, very ill with it. But it is that.
00:58:11.000 --> 00:58:13.000
Hmm.
00:58:13.000 --> 00:58:16.000
It is that stress thing, but sometimes you just don't know what's caused it.
00:58:16.000 --> 00:58:24.000
Yeah, okay. Well, I hope that answers your question, Celia. Now we've got a couple of other questions and then I think we'll need to wrap.
00:58:24.000 --> 00:58:36.000
No. Hold on 1 s. Let me just scroll down.
00:58:36.000 --> 00:58:37.000
Hmm.
00:58:37.000 --> 00:58:43.000
Yes, question from Ruth. You talk, it's coming back to smallpox again. I think it was at 2 thirds of people that caught smallpox survived.
00:58:43.000 --> 00:58:44.000
Yeah.
00:58:44.000 --> 00:58:51.000
You mean, why? Were they just generally healthier and stronger or do we know whether there was a particular reason?
00:58:51.000 --> 00:58:52.000
Okay.
00:58:52.000 --> 00:58:59.000
As far as we know, we don't know if those particular reason some people's immune systems are stronger than others.
00:58:59.000 --> 00:59:04.000
It could be that some of those people that survived had maybe had a very mild case of cowpox that they hadn't known about or something like that.
00:59:04.000 --> 00:59:22.000
It could just be that their immune system was able to fight off the disease better. I would think that probably your general health had a lot to do with it if you were well fed and you were warm.
00:59:22.000 --> 00:59:39.000
And healthy then I'm sure that your immune system would have been able to combat the smallpox easier than if you were in living in very, very poor conditions and actually not having enough to eat.
00:59:39.000 --> 00:59:45.000
Because that does affect your immune system if if you know
00:59:45.000 --> 00:59:46.000
Exactly.
00:59:46.000 --> 00:59:50.000
Hmm. Yeah, absolutely. Well, you are what you eat. And right, one final question.
00:59:50.000 --> 00:59:55.000
And then I think will wrap up. This is from, I don't know the name, it just says Jay.
00:59:55.000 --> 00:59:57.000
No, this is about It's and HIV. Are there scientists working on an AIDS vaccination?
00:59:57.000 --> 01:00:09.000
I know that there are a lot of work has gone on in terms of tackling the HIV virus.
01:00:09.000 --> 01:00:18.000
I, I think there must be. you know, when, scientists are working on things like this, they keep it.
01:00:18.000 --> 01:00:24.000
Keep it to themselves really until they've got something good enough to be able to publish and be certain.
01:00:24.000 --> 01:00:32.000
I think they're they must be definitely working on a vaccine against H HIV because it's a virus that has spread around the world.
01:00:32.000 --> 01:00:46.000
It's debilitating. It does cause deaths as we know. Obviously now we have developed treatments.
01:00:46.000 --> 01:00:52.000
Changed HIV altogether and you can live a full life as long as you know a full length life now, taking, taking the medicines.
01:00:52.000 --> 01:00:59.000
I mean, you have to take them every day. It's quite a regime. It's not that easy to follow.
01:00:59.000 --> 01:01:17.000
But it's doable and you know your your length of life won't be changed. So I don't know how much money has maybe been going into the treatment and these drugs.
01:01:17.000 --> 01:01:38.000
Against how much money went into finding a vaccine for it just remember HIV obviously we really saw the cases in the eightys in the early eightys was when we started to see it, it would have been around for a little while before that, but we were becoming aware of it in the eightys.
01:01:38.000 --> 01:02:03.000
And If HIV was was just sort of emerging now, I think there would be a bigger push on a vaccine because we have these vaccines now like the COVID one the MRNA vaccines they are easier to produce because all the testing has been, they are easier to produce because all the testing has been done on the the method.
01:02:03.000 --> 01:02:11.000
The way of, presenting the, vaccine itself. So all they change is a little bit of genetic material inside the capsule.
01:02:11.000 --> 01:02:22.000
And that's the only thing that's changed. So the testing regime is much, much easier, much quicker.
01:02:22.000 --> 01:02:23.000
Okay.
01:02:23.000 --> 01:02:29.000
So, yeah, I hope there will be one page, HIV. I think it would be really good if we could get a vaccine for it.
01:02:29.000 --> 01:02:33.000
Yeah. Okay. Well, thanks again, Catherine. That was really interesting stuff.
01:02:33.000 --> 01:02:39.000
I hope everybody out there agrees. I guess it is the subject we all have our opinions on as well and I do hope it's given you all some food for thought to find out a little bit more about it.
01:02:39.000 --> 01:02:44.000
So, and thank you Catherine.
01:02:44.000 --> 01:02:48.000
Thank you.